Schrödinger seeks aPrincipal Scientist, Biophysics,to join us in our mission to improve human health and quality of life through the development, distribution, and application of advanced computational methods.As a bench scientist on the Biophysics team with the Schrödinger Therapeutics Group, you'll collaborate with scientists and drug developers who have experience with all common target classes and therapeutic areas. We're supported by over 100 software developers and engineers, as well as a large-scale compute infrastructure to apply our proprietary physics-based drug design and optimization platform. Several of our programs have achieved development candidates, including progression to the clinic and FDA approval. You can view our entire pipeline of wholly-owned programs and collaborations here .Who will love this job:An independent scientist with extensive experience in biophysical assay development and executionA creative collaborator who can multi-task and collaborate effectively with colleagues across different disciplines and locationsA results-oriented, self-motivated team player who can work in a multidisciplinary environmentA dedicated scientist who's comfortable working across a number of drug targets and able to shift gears quickly to advance drug discovery researchAn excellent oral and written communicator who can accurately document and present scientific results according to best scientific practiceWhat you'll do:Ideate, design, and execute biophysical experiments (SPR, MST, ITC, NanoDSF, mass photometry, spectroscopy) in support of drug discovery projects, with an emphasis on hit finding and target enablementWork as a biophysical lead for drug discovery programs, managing experimental design, implementation, and execution of biophysical assays in support of drug discovery projectsProvide biophysical expertise to program teams and help enable biophysical and biochemical assay development for characterization and screeningTransfer optimized biophysical assays to CRO partners and manage CRO relationships to support, guide, and troubleshoot biophysical and biochemical experimentsReview, analyze, and interpret biophysical data and troubleshoot assays relevant to drug discovery projectsWhat you should have:PhD with at least three years of relevant hands-on experience in industry (five preferred)Expertise in establishing and troubleshooting biophysical assays with deep experience in SPR, MST, NanoDSF and/or ITCHands-on experience in running binding and mode of action assays for compound screening, MOA studies and establishing SARBackground in CRO management for execution of biophysical experimentsWe'd prefer to hire someone with:Experience with SPR using ABA injections and/or MST for MoA, ternary complex formation and competition assaysExtensive experience in hit identification/validation for drug targets in the undrugged spaceBackground in structural biology (X-ray crystallography, cryo-EM)Pay and perks:Schrödinger understands it's people that make a company great. Because of this, we're prepared to offer a competitive salary, equity-based compensation, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have regular catered meals in the office, a company culture that is relaxed but engaged, and over a month of paid vacation time. Our Office Management team also plans a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been included in Crain's New York Best Places to Work, BuiltIn's NYC Best Place to Work, and Newsweek's list of America's 100 Most Loved Workplaces. Sound exciting? Apply today and join us!As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, sexual orientation, or any other protected characteristic. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.
